Zachary Miller, MD

Associate Adjunct Professor
Neurology
[email protected]
+1 415 514-9320

Dr. Zachary Miller grew up in the Washington DC metro area. He obtained an undergraduate degree double majoring in Molecular Biology and Fine Arts from Haverford College. Following this he spent two years as a research assistant at MIT’s Whitehead Institutes for Biomedical Research in Dr. Harvey Lodish’s lab. He received his medical degree from the University of Pittsburgh and pursued medical internship as well as neurology residency training at the University of Washington.
Dr. Miller came to the UCSF Memory and Aging Center as a behavioral and cognitive neurology fellow with particular interests in enhanced creativity and visual function that can occur in the setting select neurodegenerative diseases of the language network. He completed his fellowship and is now a neurologist in the UCSF Memory and Aging Center who specializes in the care of patients suffering from cognitive decline or dementia such as Alzheimer's disease and frontotemporal dementia. His current research interests have grown to encompass the study of novel risk factors for the development of neurodegenerative disorders including neurodevelopment and chronic inflammation.

Publications: 

Perceptual and semantic deficits in face recognition in semantic dementia.

Neuropsychologia

Yadollahikhales G, Mandelli ML, Ezzes Z, Pillai J, Ratnasiri B, Baquirin DP, Miller Z, DeLeon J, Tee BL, Seeley W, Rosen H, Miller B, Kramer J, Sturm V, Gorno-Tempini ML, Montembeault M

Cross-Linguistic Analysis of Speech Markers: Insights from English, Chinese, and Italian Speakers.

medRxiv : the preprint server for health sciences

Santi GC, Catricalà E, Kwan S, Wong A, Ezzes Z, Wauters L, Esposito V, Conca F, Gibbons D, Fernandez E, Santos-Santos MA, TaFu C, Li-Ying KC, Lo R, Tsoh J, Chan LT, Garcia AM, de Leon J, Miller Z, Vonk JMJ, Bruffaerts R, Grasso SM, Allen IE, Cappa SF, Gorno-Tempini ML, Tee BL

Anatomical and behavioural correlates of auditory perception in developmental dyslexia.

Brain : a journal of neurology

Qi T, Mandelli ML, Pereira CLW, Wellman E, Bogley R, Licata AE, Miller Z, Tee BL, de Leon J, Chang EF, Oganian Y, Gorno-Tempini ML

Digital language markers distinguish frontal from right anterior temporal lobe atrophy in frontotemporal dementia.

medRxiv : the preprint server for health sciences

Vonk JMJ, Morin BT, Pillai J, Rolon DR, Bogley R, Baquirin DP, Ezzes Z, Tee BL, DeLeon J, Wauters L, Lukic S, Montembeault M, Younes K, Miller Z, García AM, Mandelli ML, Sturm VE, Miller BL, Gorno-Tempini ML

Comorbid neuropathology and atypical presentation of Alzheimer's disease.

Alzheimer's & dementia (Amsterdam, Netherlands)

Pina-Escudero SD, La Joie R, Spina S, Hwang JH, Miller ZA, Huang EJ, Grant H, Mundada NS, Boxer AL, Gorno-Tempini ML, Rosen HJ, Kramer JH, Miller BL, Seeley WW, Rabinovici GD, Grinberg LT

Perceptual and semantic deficits in face recognition in semantic dementia.

medRxiv : the preprint server for health sciences

Yadollahikhales G, Mandelli ML, Ezzes Z, Pillai J, Ratnasiri B, Baquirin DP, Miller Z, de Leon J, Tee BL, Seeley W, Rosen H, Miller B, Kramer J, Sturm V, Gorno-Tempini ML, Montembeault M

Exposure to autoimmune disorders increases Alzheimer's disease risk in a multi-site electronic health record analysis.

medRxiv : the preprint server for health sciences

Ramey GD, Tang A, Phongpreecha T, Yang MM, Woldemariam SR, Oskotsky TT, Montine TJ, Allen I, Miller ZA, Aghaeepour N, Capra JA, Sirota M

Molecular neuroimaging in dominantly inherited versus sporadic early-onset Alzheimer's disease.

Brain communications

Iaccarino L, Llibre-Guerra JJ, McDade E, Edwards L, Gordon B, Benzinger T, Hassenstab J, Kramer JH, Li Y, Miller BL, Miller Z, Morris JC, Mundada N, Perrin RJ, Rosen HJ, Soleimani-Meigooni D, Strom A, Tsoy E, Wang G, Xiong C, Allegri R, Chrem P, Vazquez S, Berman SB, Chhatwal J, Masters CL, Farlow MR, Jucker M, Levin J, Salloway S, Fox NC, Day GS, Gorno-Tempini ML, Boxer AL, La Joie R, Bateman R, Rabinovici GD

Clinical dimensions along the non-fluent variant primary progressive aphasia spectrum.

Brain : a journal of neurology

Illán-Gala I, Lorca-Puls DL, Tee BL, Ezzes Z, de Leon J, Miller ZA, Rubio-Guerra S, Santos-Santos M, Gómez-Andrés D, Grinberg LT, Spina S, Kramer JH, Wauters LD, Henry ML, Boxer AL, Rosen HJ, Miller BL, Seeley WW, Mandelli ML, Gorno-Tempini ML

Machine learning models identify predictive features of patient mortality across dementia types.

Communications medicine

Zhang J, Song L, Miller Z, Chan KCG, Huang KL

Leveraging electronic health records and knowledge networks for Alzheimer's disease prediction and sex-specific biological insights.

Nature aging

Tang AS, Rankin KP, Cerono G, Miramontes S, Mills H, Roger J, Zeng B, Nelson C, Soman K, Woldemariam S, Li Y, Lee A, Bove R, Glymour M, Aghaeepour N, Oskotsky TT, Miller Z, Allen IE, Sanders SJ, Baranzini S, Sirota M

Profiles of mathematical deficits in children with dyslexia.

NPJ science of learning

Pedemonte B, Pereira CW, Borghesani V, Ebbert M, Allen IE, Pinheiro-Chagas P, De Leon J, Miller Z, Tee BL, Gorno-Tempini ML

Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis.

The Lancet. Neurology

Chapleau M, La Joie R, Yong K, Agosta F, Allen IE, Apostolova L, Best J, Boon BDC, Crutch S, Filippi M, Fumagalli GG, Galimberti D, Graff-Radford J, Grinberg LT, Irwin DJ, Josephs KA, Mendez MF, Mendez PC, Migliaccio R, Miller ZA, Montembeault M, Murray ME, Nemes S, Pelak V, Perani D, Phillips J, Pijnenburg Y, Rogalski E, Schott JM, Seeley W, Sullivan AC, Spina S, Tanner J, Walker J, Whitwell JL, Wolk DA, Ossenkoppele R, Rabinovici GD, PCA International Work Group

Discriminating nonfluent/agrammatic and logopenic PPA variants with automatically extracted morphosyntactic measures from connected speech.

Cortex; a journal devoted to the study of the nervous system and behavior

Lukic S, Fan Z, García AM, Welch AE, Ratnasiri BM, Wilson SM, Henry ML, Vonk J, Deleon J, Miller BL, Miller Z, Mandelli ML, Gorno-Tempini ML

Neural basis of speech and grammar symptoms in non-fluent variant primary progressive aphasia spectrum.

Brain : a journal of neurology

Lorca-Puls DL, Gajardo-Vidal A, Mandelli ML, Illán-Gala I, Ezzes Z, Wauters LD, Battistella G, Bogley R, Ratnasiri B, Licata AE, Battista P, García AM, Tee BL, Lukic S, Boxer AL, Rosen HJ, Seeley WW, Grinberg LT, Spina S, Miller BL, Miller ZA, Henry ML, Dronkers NF, Gorno-Tempini ML

[18F]PI-2620 Binding Patterns in Patients with Suspected Alzheimer Disease and Frontotemporal Lobar Degeneration.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Blazhenets G, Soleimani-Meigooni DN, Thomas W, Mundada N, Brendel M, Vento S, VandeVrede L, Heuer HW, Ljubenkov P, Rojas JC, Chen MK, Amuiri AN, Miller Z, Gorno-Tempini ML, Miller BL, Rosen HJ, Litvan I, Grossman M, Boeve B, Pantelyat A, Tartaglia MC, Irwin DJ, Dickerson BC, Baker SL, Boxer AL, Rabinovici GD, La Joie R

Assessing processing speed and its neural correlates in the three variants of primary progressive aphasia with a non-verbal tablet-based task.

Cortex; a journal devoted to the study of the nervous system and behavior

Gajardo-Vidal A, Montembeault M, Lorca-Puls DL, Licata AE, Bogley R, Erlhoff S, Ratnasiri B, Ezzes Z, Battistella G, Tsoy E, Pereira CW, DeLeon J, Tee BL, Henry ML, Miller ZA, Rankin KP, Mandelli ML, Possin KL, Gorno-Tempini ML

Longitudinal clinical, cognitive and biomarker profiles in dominantly inherited versus sporadic early-onset Alzheimer's disease.

Brain communications

Llibre-Guerra JJ, Iaccarino L, Coble D, Edwards L, Li Y, McDade E, Strom A, Gordon B, Mundada N, Schindler SE, Tsoy E, Ma Y, Lu R, Fagan AM, Benzinger TLS, Soleimani-Meigooni D, Aschenbrenner AJ, Miller Z, Wang G, Kramer JH, Hassenstab J, Rosen HJ, Morris JC, Miller BL, Xiong C, Perrin RJ, Allegri R, Chrem P, Surace E, Berman SB, Chhatwal J, Masters CL, Farlow MR, Jucker M, Levin J, Fox NC, Day G, Gorno-Tempini ML, Boxer AL, La Joie R, Rabinovici GD, Bateman R

Diminished baseline autonomic outflow in semantic dementia relates to left-lateralized insula atrophy.

NeuroImage. Clinical

Hua AY, Roy ARK, Kosik EL, Morris NA, Chow TE, Lukic S, Montembeault M, Borghesani V, Younes K, Kramer JH, Seeley WW, Perry DC, Miller ZA, Rosen HJ, Miller BL, Rankin KP, Gorno-Tempini ML, Sturm VE

Early-onset Alzheimer's disease explained by polygenic risk of late-onset disease?

Alzheimer's & dementia (Amsterdam, Netherlands)

Mantyh WG, Cochran JN, Taylor JW, Broce IJ, Geier EG, Bonham LW, Anderson AG, Sirkis DW, Joie R, Iaccarino L, Chaudhary K, Edwards L, Strom A, Grant H, Allen IE, Miller ZA, Gorno-Tempini ML, Kramer JH, Miller BL, Desikan RS, Rabinovici GD, Yokoyama JS

Distinct neurophysiology during nonword repetition in logopenic and non-fluent variants of primary progressive aphasia.

Human brain mapping

Hinkley LBN, Thompson M, Miller ZA, Borghesani V, Mizuiri D, Shwe W, Licata A, Ninomiya S, Lauricella M, Mandelli ML, Miller BL, Houde J, Gorno-Tempini ML, Nagarajan SS

Rigorous benchmarking of T-cell receptor repertoire profiling methods for cancer RNA sequencing.

Briefings in bioinformatics

Peng K, Nowicki TS, Campbell K, Vahed M, Peng D, Meng Y, Nagareddy A, Huang YN, Karlsberg A, Miller Z, Brito J, Nadel B, Pak VM, Abedalthagafi MS, Burkhardt AM, Alachkar H, Ribas A, Mangul S

Expressive Prosody in Patients With Focal Anterior Temporal Neurodegeneration.

Neurology

Geraudie A, Pressman PS, Pariente J, Millanski C, Palser ER, Ratnasiri BM, Battistella G, Mandelli ML, Miller ZA, Miller BL, Sturm V, Rankin KP, Gorno-Tempini ML, Montembeault M

Network anatomy in logopenic variant of primary progressive aphasia.

Human brain mapping

Mandelli ML, Lorca-Puls DL, Lukic S, Montembeault M, Gajardo-Vidal A, Licata A, Scheffler A, Battistella G, Grasso SM, Bogley R, Ratnasiri BM, La Joie R, Mundada NS, Europa E, Rabinovici G, Miller BL, De Leon J, Henry ML, Miller Z, Gorno-Tempini ML

Network anatomy in logopenic variant of primary progressive aphasia.

medRxiv : the preprint server for health sciences

Mandelli ML, Lorca-Puls DL, Lukic S, Montembeault M, Gajardo-Vidal A, Licata A, Scheffler A, Battistella G, Grasso SM, Bogley R, Ratnasiri BM, La Joie R, Mundada NS, Europa E, Rabinovici G, Miller BL, De Leon J, Henry ML, Miller Z, Gorno-Tempini ML

Prevalence, Timing, and Network Localization of Emergent Visual Creativity in Frontotemporal Dementia.

JAMA neurology

Friedberg A, Pasquini L, Diggs R, Glaubitz EA, Lopez L, Ill?n-Gala I, Iaccarino L, La Joie R, Mundada N, Knudtson M, Neylan K, Brown J, Allen IE, Rankin KP, Bonham LW, Yokoyama JS, Ramos EM, Geschwind DH, Spina S, Grinberg LT, Miller ZA, Kramer JH, Rosen H, Gorno-Tempini ML, Rabinovici G, Seeley WW, Miller BL

Spared speech fluency is associated with increased functional connectivity in the speech production network in semantic variant primary progressive aphasia.

Brain communications

Montembeault M, Miller ZA, Geraudie A, Pressman P, Slegers A, Millanski C, Licata A, Ratnasiri B, Mandelli ML, Henry M, Cobigo Y, Rosen HJ, Miller BL, Brambati SM, Gorno-Tempini ML, Battistella G

Amyloid, tau and metabolic PET correlates of cognition in early and late-onset Alzheimer's disease.

Brain : a journal of neurology

Tanner JA, Iaccarino L, Edwards L, Asken BM, Gorno-Tempini ML, Kramer JH, Pham J, Perry DC, Possin K, Malpetti M, Mellinger T, Miller BL, Miller Z, Mundada NS, Rosen HJ, Soleimani-Meigooni DN, Strom A, La Joie R, Rabinovici GD

Visual and social differences in dyslexia: deep phenotyping of four cases with spared phonology.

Neurocase

Palser ER, Miller ZA, Licata AE, Yabut NA, Sudarsan SP, Tee BL, Deleon JA, Mandelli ML, Caverzasi E, Sturm VE, Hendren R, Possin KL, Miller BL, Gorno Tempini ML, Watson Pereira C

Right temporal lobe and socioemotional semantics: semantic behavioural variant frontotemporal dementia.

Brain : a journal of neurology

Younes K, Borghesani V, Montembeault M, Spina S, Mandelli ML, Welch AE, Weis E, Callahan P, Elahi FM, Hua AY, Perry DC, Karydas A, Geschwind D, Huang E, Grinberg LT, Kramer JH, Boxer AL, Rabinovici GD, Rosen HJ, Seeley WW, Miller ZA, Miller BL, Sturm VE, Rankin KP, Luisa Gorno-Tempini M

Laryngeal myoclonus related to vagal nerve stimulation.

Ear, nose, & throat journal

Behnke J, Miller Z, Turner M, McChesney J

Neuroimmune dysfunction in frontotemporal dementia: Insights from progranulin and C9orf72 deficiency.

Current opinion in neurobiology

Hashimoto K, Jahan N, Miller ZA, Huang EJ

Auditory Verb Generation Performance Patterns Dissociate Variants of Primary Progressive Aphasia.

Frontiers in psychology

Lukic S, Licata AE, Weis E, Bogley R, Ratnasiri B, Welch AE, Hinkley LBN, Miller Z, Garcia AM, Houde JF, Nagarajan SS, Gorno-Tempini ML, Borghesani V

Probabilistic Decision-Making in Children With Dyslexia.

Frontiers in neuroscience

Pereira CLW, Zhou R, Pitt MA, Myung JI, Rossi PJ, Caverzasi E, Rah E, Allen IE, Mandelli ML, Meyer M, Miller ZA, Gorno Tempini ML

Neuroanatomical correlations of visuospatial processing in primary progressive aphasia.

Brain communications

Tee BL, Watson Pereira C, Lukic S, Bajorek LP, Allen IE, Miller ZA, Casaletto KB, Miller BL, Gorno-Tempini ML

Speech and language impairments in behavioral variant frontotemporal dementia: A systematic review.

Neuroscience and biobehavioral reviews

Geraudie A, Battista P, García AM, Allen IE, Miller ZA, Gorno-Tempini ML, Montembeault M

Children with developmental dyslexia show elevated parasympathetic nervous system activity at rest and greater cardiac deceleration during an empathy task.

Biological psychology

Palser ER, Morris NA, Roy ARK, Holley SR, Veziris CR, Watson C, Deleon J, Miller ZA, Miller BL, Gorno-Tempini ML, Sturm VE

Development of an Abbreviated Adult Reading History Questionnaire (ARHQ-Brief) Using a Machine Learning Approach.

Journal of learning disabilities

Feng L, Hancock R, Watson C, Bogley R, Miller ZA, Gorno-Tempini ML, Briggs-Gowan MJ, Hoeft F

The resilience of the developing reading system: multi-modal evidence of incident and recovery after a pediatric stroke.

Neurocase

Borghesani V, Wang C, Miller C, Mandelli ML, Shapiro K, Miller Z, Fox C, Dronkers NF, Gorno-Tempini ML, Watson C

Comorbid neuropathological diagnoses in early versus late-onset Alzheimer's disease.

Brain : a journal of neurology

Spina S, La Joie R, Petersen C, Nolan AL, Cuevas D, Cosme C, Hepker M, Hwang JH, Miller ZA, Huang EJ, Karydas AM, Grant H, Boxer AL, Gorno-Tempini ML, Rosen HJ, Kramer JH, Miller BL, Seeley WW, Rabinovici GD, Grinberg LT

Neural dynamics of semantic categorization in semantic variant of primary progressive aphasia.

eLife

Borghesani V, Dale CL, Lukic S, Hinkley L, Lauricella M, Shwe W, Mizuiri D, Honma S, Miller Z, Miller B, Houde JF, Gorno-Tempini ML, Nagarajan SS

Functional and morphological correlates of developmental dyslexia: A multimodal investigation of the ventral occipitotemporal cortex.

Journal of neuroimaging : official journal of the American Society of Neuroimaging

Borghesani V, Wang C, Watson C, Bouhali F, Caverzasi E, Battistella G, Bogley R, Yabut NA, Deleon J, Miller ZA, Hoeft F, Mandelli ML, Gorno-Tempini ML

Dissociating nouns and verbs in temporal and perisylvian networks: Evidence from neurodegenerative diseases.

Cortex; a journal devoted to the study of the nervous system and behavior

Lukic S, Borghesani V, Weis E, Welch A, Bogley R, Neuhaus J, Deleon J, Miller ZA, Kramer JH, Miller BL, Dronkers NF, Gorno-Tempini ML

Cortically constrained shape recognition: Automated white matter tract segmentation validated in the pediatric brain.

Journal of neuroimaging : official journal of the American Society of Neuroimaging

Association of APOE4 and clinical variability in Alzheimer disease with the pattern of tau- and amyloid-PET.

Neurology

La Joie R, Visani AV, Lesman-Segev OH, Baker SL, Edwards L, Iaccarino L, Soleimani-Meigooni DN, Mellinger T, Janabi M, Miller ZA, Perry DC, Pham J, Strom A, Gorno-Tempini ML, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD

Enhanced visceromotor emotional reactivity in dyslexia and its relation to salience network connectivity.

Cortex; a journal devoted to the study of the nervous system and behavior

Sturm VE, Roy ARK, Datta S, Wang C, Sible IJ, Holley SR, Watson C, Palser ER, Morris NA, Battistella G, Rah E, Meyer M, Pakvasa M, Mandelli ML, Deleon J, Hoeft F, Caverzasi E, Miller ZA, Shapiro KA, Hendren R, Miller BL, Gorno-Tempini ML

Effects of bilingualism on age at onset in two clinical Alzheimer's disease variants.

Alzheimer's & dementia : the journal of the Alzheimer's Association

de Leon J, Grasso SM, Welch A, Miller Z, Shwe W, Rabinovici GD, Miller BL, Henry ML, Gorno-Tempini ML

Tracheal Squamous Cell Carcinoma Treated with Tracheal Resection and Anastomosis in a Cat.

Case reports in veterinary medicine

Miller ZA, Padgett S, Terreros A, Pearce E

Regional and hemispheric susceptibility of the temporal lobe to FTLD-TDP type C pathology.

NeuroImage. Clinical

Borghesani V, Battistella G, Mandelli ML, Welch A, Weis E, Younes K, Neuhaus J, Grinberg LT, Seeley WM, Spina S, Miller B, Miller Z, Gorno-Tempini ML

Taking the sublexical route: brain dynamics of reading in the semantic variant of primary progressive aphasia.

Brain : a journal of neurology

Borghesani V, Hinkley LBN, Ranasinghe KG, Thompson MMC, Shwe W, Mizuiri D, Lauricella M, Europa E, Honma S, Miller Z, Miller B, Vossel K, Henry MML, Houde JF, Gorno-Tempini ML, Nagarajan SS

Temporal variant of frontotemporal dementia in C9orf72 repeat expansion carriers: two case studies.

Brain imaging and behavior

Caso F, Agosta F, Magnani G, Cardamone R, Borghesani V, Miller Z, Riva N, La Joie R, Coppola G, Grinberg LT, Seeley WW, Miller BL, Gorno-Tempini ML, Filippi M

Reactions to Multiple Ascending Doses of the Microtubule Stabilizer TPI-287 in Patients With Alzheimer Disease, Progressive Supranuclear Palsy, and Corticobasal Syndrome: A Randomized Clinical Trial.

JAMA neurology

Tsai RM, Miller Z, Koestler M, Rojas JC, Ljubenkov PA, Rosen HJ, Rabinovici GD, Fagan AM, Cobigo Y, Brown JA, Jung JI, Hare E, Geldmacher DS, Natelson-Love M, McKinley EC, Luong PN, Chuu EL, Powers R, Mumford P, Wolf A, Wang P, Shamloo M, Miller BL, Roberson ED, Boxer AL

Language and spatial dysfunction in Alzheimer disease with white matter thorn-shaped astrocytes: Astrocytic tau, cognitive function, and Alzheimer disease.

Neurology

Resende EPF, Nolan AL, Petersen C, Ehrenberg AJ, Spina S, Allen IE, Rosen HJ, Kramer J, Miller BL, Seeley WW, Gorno-Tempini ML, Miller Z, Grinberg LT

Prospective longitudinal atrophy in Alzheimer's disease correlates with the intensity and topography of baseline tau-PET.

Science translational medicine

La Joie R, Visani AV, Baker SL, Brown JA, Bourakova V, Cha J, Chaudhary K, Edwards L, Iaccarino L, Janabi M, Lesman-Segev OH, Miller ZA, Perry DC, O'Neil JP, Pham J, Rojas JC, Rosen HJ, Seeley WW, Tsai RM, Miller BL, Jagust WJ, Rabinovici GD

Task-free functional language networks: reproducibility and clinical application.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Battistella G, Borghesani V, Henry M, Shwe W, Lauricella M, Miller Z, Deleon J, Miller BL, Dronkers N, Brambati SM, Seeley WW, Luisa Mandelli M, Luisa Gorno-Tempini M

Astrocytic Tau Deposition Is Frequent in Typical and Atypical Alzheimer Disease Presentations.

Journal of neuropathology and experimental neurology

Nolan A, De Paula Franca Resende E, Petersen C, Neylan K, Spina S, Huang E, Seeley W, Miller Z, Grinberg LT

Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia.

Brain communications

Miller ZA, Spina S, Pakvasa M, Rosenberg L, Watson C, Mandelli ML, Paredes MF, Joie R, Rabinovici GD, Rosen HJ, Grinberg LT, Huang EJ, Miller BL, Seeley WW, Gorno-Tempini ML

Peripheral Innate Immune Activation Correlates With Disease Severity in GRN Haploinsufficiency.

Frontiers in neurology

Ljubenkov PA, Miller Z, Mumford P, Zhang J, Allen IE, Mitic L, Staffaroni A, Heuer H, Rojas JC, Cobigo Y, Karydas A, Pearlman R, Miller B, Kramer JH, McGrath MS, Rosen HJ, Boxer AL

Verbal Semantics and the Left Dorsolateral Anterior Temporal Lobe: A Longitudinal Case of Bilateral Temporal Degeneration.

Aphasiology

Vonk JMJ, Borghesani V, Battistella G, Younes K, DeLeon J, Welch A, Hubbard HI, Miller ZA, Miller BL, Gorno-Tempini ML

Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia.

Scientific reports

Bonham LW, Steele NZR, Karch CM, Broce I, Geier EG, Wen NL, Momeni P, Hardy J, Miller ZA, Gorno-Tempini ML, Hess CP, Lewis P, Miller BL, Seeley WW, Manzoni C, Desikan RS, Baranzini SE, Ferrari R, Yokoyama JS

Alzheimer's disease clinical variants show distinct regional patterns of neurofibrillary tangle accumulation.

Acta neuropathologica

Petersen C, Nolan AL, de Paula França Resende E, Miller Z, Ehrenberg AJ, Gorno-Tempini ML, Rosen HJ, Kramer JH, Spina S, Rabinovici GD, Miller BL, Seeley WW, Heinsen H, Grinberg LT

Factors that predict diagnostic stability in neurodegenerative dementia.

Journal of neurology

Perry DC, Datta S, Miller ZA, Rankin KP, Gorno-Tempini ML, Kramer JH, Rosen HJ, Seeley WW, Miller BL

Neurocognitive basis of repetition deficits in primary progressive aphasia.

Brain and language

Lukic S, Mandelli ML, Welch A, Jordan K, Shwe W, Neuhaus J, Miller Z, Hubbard HI, Henry M, Miller BL, Dronkers NF, Gorno-Tempini ML

Atypical clinical features associated with mixed pathology in a case of non-fluent variant primary progressive aphasia.

Neurocase

De Leon J, Mandelli ML, Nolan A, Miller ZA, Mead C, Watson C, Welch AE, Henry ML, Bourakova V, La Joie R, Bajorek LP, Grinberg L, Rabinovici G, Miller BL, Gorno-Tempini ML

Dopamine receptor D4 (DRD4) polymorphisms with reduced functional potency intensify atrophy in syndrome-specific sites of frontotemporal dementia.

NeuroImage. Clinical

Butler PM, Chiong W, Perry DC, Miller ZA, Gennatas ED, Brown JA, Pasquini L, Karydas A, Dokuru D, Coppola G, Sturm VE, Boxer AL, Gorno-Tempini ML, Rosen HJ, Kramer JH, Miller BL, Seeley WW

Differential intrinsic functional connectivity changes in semantic variant primary progressive aphasia.

NeuroImage. Clinical

Battistella G, Henry M, Gesierich B, Wilson SM, Borghesani V, Shwe W, Miller Z, Deleon J, Miller BL, Jovicich J, Papinutto N, Dronkers NF, Seeley WW, Mandelli ML, Gorno-Tempini ML

Genetic screen in a large series of patients with primary progressive aphasia.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Ramos EM, Dokuru DR, Van Berlo V, Wojta K, Wang Q, Huang AY, Miller ZA, Karydas AM, Bigio EH, Rogalski E, Weintraub S, Rader B, Miller BL, Gorno-Tempini ML, Mesulam MM, Coppola G

"Looks familiar, but I do not know who she is": The role of the anterior right temporal lobe in famous face recognition.

Cortex; a journal devoted to the study of the nervous system and behavior

Borghesani V, Narvid J, Battistella G, Shwe W, Watson C, Binney RJ, Sturm V, Miller Z, Mandelli ML, Miller B, Gorno-Tempini ML

Primary progressive aphasia and the FTD-MND spectrum disorders: clinical, pathological, and neuroimaging correlates.

Amyotrophic lateral sclerosis & frontotemporal degeneration

Vinceti G, Olney N, Mandelli ML, Spina S, Hubbard HI, Santos-Santos MA, Watson C, Miller ZA, Lomen-Hoerth C, Nichelli P, Miller BL, Grinberg LT, Seeley WW, Gorno-Tempini ML

Mixed TDP-43 proteinopathy and tauopathy in frontotemporal lobar degeneration: nine case series.

Journal of neurology

Kim EJ, Brown JA, Deng J, Hwang JL, Spina S, Miller ZA, DeMay MG, Valcour V, Karydas A, Ramos EM, Coppola G, Miller BL, Rosen HJ, Seeley WW, Grinberg LT

Protein network analysis reveals selectively vulnerable regions and biological processes in FTD.

Neurology. Genetics

Bonham LW, Steele NZR, Karch CM, Manzoni C, Geier EG, Wen N, Ofori-Kuragu A, Momeni P, Hardy J, Miller ZA, Hess CP, Lewis P, Miller BL, Seeley WW, Baranzini SE, Desikan RS, Ferrari R, Yokoyama JS

Altered topology of the functional speech production network in non-fluent/agrammatic variant of PPA.

Cortex; a journal devoted to the study of the nervous system and behavior

Mandelli ML, Welch AE, Vilaplana E, Watson C, Battistella G, Brown JA, Possin KL, Hubbard HI, Miller ZA, Henry ML, Marx GA, Santos-Santos MA, Bajorek LP, Fortea J, Boxer A, Rabinovici G, Lee S, Deleon J, Rosen HJ, Miller BL, Seeley WW, Gorno-Tempini ML

Prevalence of Mathematical and Visuospatial Learning Disabilities in Patients With Posterior Cortical Atrophy.

JAMA neurology

Miller ZA, Rosenberg L, Santos-Santos MA, Stephens M, Allen IE, Hubbard HI, Cantwell A, Mandelli ML, Grinberg LT, Seeley WW, Miller BL, Rabinovici GD, Gorno-Tempini ML

Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.

Nature medicine

Wang C, Najm R, Xu Q, Jeong DE, Walker D, Balestra ME, Yoon SY, Yuan H, Li G, Miller ZA, Miller BL, Malloy MJ, Huang Y

Artistic Renaissance in Frontotemporal Dementia.

JAMA

Erkkinen MG, Zúñiga RG, Pardo CC, Miller BL, Miller ZA

Abnormal age-related cortical folding and neurite morphology in children with developmental dyslexia.

NeuroImage. Clinical

Caverzasi E, Mandelli ML, Hoeft F, Watson C, Meyer M, Allen IE, Papinutto N, Wang C, Gandini Wheeler-Kingshott CAM, Marco EJ, Mukherjee P, Miller ZA, Miller BL, Hendren R, Shapiro KA, Gorno-Tempini ML

Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.

JAMA neurology

Santos-Santos MA, Rabinovici GD, Iaccarino L, Ayakta N, Tammewar G, Lobach I, Henry ML, Hubbard I, Mandelli ML, Spinelli E, Miller ZA, Pressman PS, O'Neil JP, Ghosh P, Lazaris A, Meyer M, Watson C, Yoon SJ, Rosen HJ, Grinberg L, Seeley WW, Miller BL, Jagust WJ, Gorno-Tempini ML

Correction: Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.

PLoS medicine

Broce I, Karch CM, Wen N, Fan CC, Wang Y, Tan CH, Kouri N, Ross OA, Höglinger GU, Muller U, Hardy J

Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.

PLoS medicine

Broce I, Karch CM, Wen N, Fan CC, Wang Y, Tan CH, Kouri N, Ross OA, Höglinger GU, Muller U, Hardy J

Associations between [18F]AV1451 tau PET and CSF measures of tau pathology in a clinical sample.

Neurology

La Joie R, Bejanin A, Fagan AM, Ayakta N, Baker SL, Bourakova V, Boxer AL, Cha J, Karydas A, Jerome G, Maass A, Mensing A, Miller ZA, O'Neil JP, Pham J, Rosen HJ, Tsai R, Visani AV, Miller BL, Jagust WJ, Rabinovici GD

Clinicopathological correlations in behavioural variant frontotemporal dementia.

Brain : a journal of neurology

Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, Lee SE, Matthews BR, Kao AW, Vossel KA, Tartaglia MC, Miller ZA, Seo SW, Sidhu M, Gaus SE, Nana AL, Vargas JNS, Hwang JL, Ossenkoppele R, Brown AB, Huang EJ, Coppola G, Rosen HJ, Geschwind D, Trojanowski JQ, Grinberg LT, Kramer JH, Miller BL, Seeley WW

Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease.

Brain : a journal of neurology

Bejanin A, Schonhaut DR, La Joie R, Kramer JH, Baker SL, Sosa N, Ayakta N, Cantwell A, Janabi M, Lauriola M, O'Neil JP, Gorno-Tempini ML, Miller ZA, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD

Visuospatial Functioning in the Primary Progressive Aphasias.

Journal of the International Neuropsychological Society : JINS

Watson CL, Possin K, Allen IE, Hubbard HI, Meyer M, Welch AE, Rabinovici GD, Rosen H, Rankin KP, Miller Z, Santos-Santos MA, Kramer JH, Miller BL, Gorno-Tempini ML

Distinct spatiotemporal patterns of neuronal functional connectivity in primary progressive aphasia variants.

Brain : a journal of neurology

Ranasinghe KG, Hinkley LB, Beagle AJ, Mizuiri D, Honma SM, Welch AE, Hubbard I, Mandelli ML, Miller ZA, Garrett C, La A, Boxer AL, Houde JF, Miller BL, Vossel KA, Gorno-Tempini ML, Nagarajan SS

Local and distant relationships between amyloid, tau and neurodegeneration in Alzheimer's Disease.

NeuroImage. Clinical

Iaccarino L, Tammewar G, Ayakta N, Baker SL, Bejanin A, Boxer AL, Gorno-Tempini ML, Janabi M, Kramer JH, Lazaris A, Lockhart SN, Miller BL, Miller ZA, O'Neil JP, Ossenkoppele R, Rosen HJ, Schonhaut DR, Jagust WJ, Rabinovici GD

An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations.

Alzheimer's & dementia (New York, N. Y.)

Sha SJ, Miller ZA, Min SW, Zhou Y, Brown J, Mitic LL, Karydas A, Koestler M, Tsai R, Corbetta-Rastelli C, Lin S, Hare E, Fields S, Fleischmann KE, Powers R, Fitch R, Martens LH, Shamloo M, Fagan AM, Farese RV, Pearlman R, Seeley W, Miller BL, Gan L, Boxer AL

Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study.

PLoS medicine

Steele NZ, Carr JS, Bonham LW, Geier EG, Damotte V, Miller ZA, Desikan RS, Boehme KL, Mukherjee S, Crane PK, Kauwe JS, Kramer JH, Miller BL, Coppola G, Hollenbach JA, Huang Y, Yokoyama JS

Typical and atypical pathology in primary progressive aphasia variants.

Annals of neurology

Spinelli EG, Mandelli ML, Miller ZA, Santos-Santos MA, Wilson SM, Agosta F, Grinberg LT, Huang EJ, Trojanowski JQ, Meyer M, Henry ML, Comi G, Rabinovici G, Rosen HJ, Filippi M, Miller BL, Seeley WW, Gorno-Tempini ML

Genetic Prion Disease Caused by PRNP Q160X Mutation Presenting with an Orbitofrontal Syndrome, Cyclic Diarrhea, and Peripheral Neuropathy.

Journal of Alzheimer's disease : JAD

Fong JC, Rojas JC, Bang J, Legati A, Rankin KP, Forner S, Miller ZA, Karydas AM, Coppola G, Grouse CK, Ralph J, Miller BL, Geschwind MD

Increased prevalence of autoimmune disease within C9 and FTD/MND cohorts: Completing the picture.

Neurology(R) neuroimmunology & neuroinflammation

Miller ZA, Sturm VE, Camsari GB, Karydas A, Yokoyama JS, Grinberg LT, Boxer AL, Rosen HJ, Rankin KP, Gorno-Tempini ML, Coppola G, Geschwind DH, Rademakers R, Seeley WW, Graff-Radford NR, Miller BL

Cognition and neuropsychiatry in behavioral variant frontotemporal dementia by disease stage.

Neurology

Bertoux M, Sarazin M, Pasquier F, Bottlaender M, de Souza LC, Mioshi E, Hornberger M, Ranasinghe KG, Rankin KP, Lobach IV, Kramer JH, Sturm VE, Bettcher BM, Possin K, You SC, Lamarre AK, Shany-Ur T, Stephens ML, Perry DC, Lee SE, Miller ZA, Gorno-Tempini ML, Rosen HJ, Boxer A, Seeley WW, Rabinovici GD, Vossel KA, Miller BL

Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression.

Acta neuropathologica communications

Sirkis DW, Bonham LW, Aparicio RE, Geier EG, Ramos EM, Wang Q, Karydas A, Miller ZA, Miller BL, Coppola G, Yokoyama JS

Distinct Subtypes of Behavioral Variant Frontotemporal Dementia Based on Patterns of Network Degeneration.

JAMA neurology

Ranasinghe KG, Rankin KP, Pressman PS, Perry DC, Lobach IV, Seeley WW, Coppola G, Karydas AM, Grinberg LT, Shany-Ur T, Lee SE, Rabinovici GD, Rosen HJ, Gorno-Tempini ML, Boxer AL, Miller ZA, Chiong W, DeMay M, Kramer JH, Possin KL, Sturm VE, Bettcher BM, Neylan M, Zackey DD, Nguyen LA, Ketelle R, Block N, Wu TQ, Dallich A, Russek N, Caplan A, Geschwind DH, Vossel KA, Miller BL

Healthy brain connectivity predicts atrophy progression in non-fluent variant of primary progressive aphasia.

Brain : a journal of neurology

Mandelli ML, Vilaplana E, Brown JA, Hubbard HI, Binney RJ, Attygalle S, Santos-Santos MA, Miller ZA, Pakvasa M, Henry ML, Rosen HJ, Henry RG, Rabinovici GD, Miller BL, Seeley WW, Gorno-Tempini ML

MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes.

Alzheimer's & dementia (Amsterdam, Netherlands)

Bettcher BM, Fitch R, Wynn MJ, Lalli MA, Elofson J, Jastrzab L, Mitic L, Miller ZA, Rabinovici GD, Miller BL, Kao AW, Kosik KS, Kramer JH

Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease.

JAMA neurology

Yokoyama JS, Wang Y, Schork AJ, Thompson WK, Karch CM, Cruchaga C, McEvoy LK, Witoelar A, Chen CH, Holland D, Brewer JB, Franke A, Dillon WP, Wilson DM, Mukherjee P, Hess CP, Miller Z, Bonham LW, Shen J, Rabinovici GD, Rosen HJ, Miller BL, Hyman BT, Schellenberg GD, Karlsen TH, Andreassen OA, Dale AM, Desikan RS

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease.

Brain : a journal of neurology

Ossenkoppele R, Schonhaut DR, Schöll M, Lockhart SN, Ayakta N, Baker SL, O'Neil JP, Janabi M, Lazaris A, Cantwell A, Vogel J, Santos M, Miller ZA, Bettcher BM, Vossel KA, Kramer JH, Gorno-Tempini ML, Miller BL, Jagust WJ, Rabinovici GD

Cognition and neuropsychiatry in behavioral variant frontotemporal dementia by disease stage.

Neurology

Ranasinghe KG, Rankin KP, Lobach IV, Kramer JH, Sturm VE, Bettcher BM, Possin K, Christine You S, Lamarre AK, Shany-Ur T, Stephens ML, Perry DC, Lee SE, Miller ZA, Gorno-Tempini ML, Rosen HJ, Boxer A, Seeley WW, Rabinovici GD, Vossel KA, Miller BL

Phonological Processing in Primary Progressive Aphasia.

Journal of cognitive neuroscience

Henry ML, Wilson SM, Babiak MC, Mandelli ML, Beeson PM, Miller ZA, Gorno-Tempini ML

Loss of functional connectivity is greater outside the default mode network in nonfamilial early-onset Alzheimer's disease variants.

Neurobiology of aging

Lehmann M, Madison C, Ghosh PM, Miller ZA, Greicius MD, Kramer JH, Coppola G, Miller BL, Jagust WJ, Gorno-Tempini ML, Seeley WW, Rabinovici GD

A novel mutation P112H in the TARDBP gene associated with frontotemporal lobar degeneration without motor neuron disease and abundant neuritic amyloid plaques.

Acta neuropathologica communications

Moreno F, Rabinovici GD, Karydas A, Miller Z, Hsu SC, Legati A, Fong J, Schonhaut D, Esselmann H, Watson C, Stephens ML, Kramer J, Wiltfang J, Seeley WW, Miller BL, Coppola G, Grinberg LT

Longitudinal gray matter contraction in three variants of primary progressive aphasia: A tenser-based morphometry study.

NeuroImage. Clinical

Brambati SM, Amici S, Racine CA, Neuhaus J, Miller Z, Ogar J, Dronkers N, Miller BL, Rosen H, Gorno-Tempini ML

Tau, amyloid, and hypometabolism in a patient with posterior cortical atrophy.

Annals of neurology

Ossenkoppele R, Schonhaut DR, Baker SL, O'Neil JP, Janabi M, Ghosh PM, Santos M, Miller ZA, Bettcher BM, Gorno-Tempini ML, Miller BL, Jagust WJ, Rabinovici GD

Anomalous functional language lateralization in semantic variant PPA.

Neurology

Miller ZA, Hinkley LB, Herman A, Honma S, Findlay A, Block N, Ketelle R, Rabinovici G, Rosen H, Nagarajan SS, Miller BL, Gorno-Tempini ML

Divergent CSF t alterations in two common tauopathies: Alzheimer's disease and progressive supranuclear palsy.

Journal of neurology, neurosurgery, and psychiatry

Wagshal D, Sankaranarayanan S, Guss V, Hall T, Berisha F, Lobach I, Karydas A, Voltarelli L, Scherling C, Heuer H, Tartaglia MC, Miller Z, Coppola G, Ahlijanian M, Soares H, Kramer JH, Rabinovici GD, Rosen HJ, Miller BL, Meredith J, Boxer AL

Verbal creativity in semantic variant primary progressive aphasia.

Neurocase

Wu TQ, Miller ZA, Adhimoolam B, Zackey DD, Khan BK, Ketelle R, Rankin KP, Miller BL

Handedness and language learning disability differentially distribute in progressive aphasia variants.

Brain : a journal of neurology

Miller ZA, Mandelli ML, Rankin KP, Henry ML, Babiak MC, Frazier DT, Lobach IV, Bettcher BM, Wu TQ, Rabinovici GD, Graff-Radford NR, Miller BL, Gorno-Tempini ML

Interrater reliability of the new criteria for behavioral variant frontotemporal dementia.

Neurology

Lamarre AK, Rascovsky K, Bostrom A, Toofanian P, Wilkins S, Sha SJ, Perry DC, Miller ZA, Naasan G, Laforce R, Hagen J, Takada LT, Tartaglia MC, Kang G, Galasko D, Salmon DP, Farias ST, Kaur B, Olichney JM, Quitania Park L, Mendez MF, Tsai PH, Teng E, Dickerson BC, Domoto-Reilly K, McGinnis S, Miller BL, Kramer JH

TDP-43 frontotemporal lobar degeneration and autoimmune disease.

Journal of neurology, neurosurgery, and psychiatry

Miller ZA, Rankin KP, Graff-Radford NR, Takada LT, Sturm VE, Cleveland CM, Criswell LA, Jaeger PA, Stan T, Heggeli KA, Hsu SC, Karydas A, Khan BK, Grinberg LT, Gorno-Tempini ML, Boxer AL, Rosen HJ, Kramer JH, Coppola G, Geschwind DH, Rademakers R, Seeley WW, Wyss-Coray T, Miller BL

Artistic creativity and dementia.

Progress in brain research

Miller ZA, Miller BL

Synergism between transcription factors TFE3 and Smad3 in transforming growth factor-beta-induced transcription of the Smad7 gene.

The Journal of biological chemistry

Hua X, Miller ZA, Benchabane H, Wrana JL, Lodish HF